Full Name: Shao-Hua Wang

Position: Ph.D，Professor

E-mail: wangshh@lzu.edu.cn

Address:

School of Pharmacy，Lanzhou University, Lanzhou730000, China

Education:

Sep.2001~Jun.2006

Ph.D. degree at Lanzhou University, Major in organic Chemistry

Sep.1997~Jul.2001

B.Sc. degree at Lanzhou University, Major in Chemistry

Professional Background:

May.2017~present

Professor of Medicinal Chemistry, School of Pharmacy，Lanzhou University

Aug. 2011~Apr.2017

Associate Professor of Medicinal Chemistry, School of Pharmacy，Lanzhou University

Jun. 2006~Jul.2011

Research Associate, Mayo Clinic

Teaching:

Courses:

Analytical Chemistry (for undergraduate students)

Textbook:

<Analytical Chemistry>, China Medical Science Press, Sept. 2010,

Research Interests:

Research experience

Responsible for and participate in research projects: “the General Program of National Natural Science Foundation of China”

Research Interests

1. Development of small-molecule therapeutics for treating diseases such as cancers and botulism;

2. Development of new methodologies for syntheses of drug-like molecules;

3. Synthesis of bioactive molecules

Honor and Awards:

2017, Gansu Young Teacher Achievement Award.

2016, Second Level National Prize for Natural Sciences.

2015, First Level Natural Science Awardof The Ministryof Education.

Representative Publications:

1.Shao, H.; Bao, W.; Jing, Z.-R.; Wang, Y.-P.; Zhang, F.-M.; Wang, S.-H.; Tu, Y.-Q., Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction. organic Letters 2017,19 (17), 4648-4651;

2.Liu, L.; Cheng, H.-L.; Ma, W.-Q.; Hou, S.-H.; Tu, Y.-Q.; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H., Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Chemical Communications 2018,54 (2), 196-199;

3.Zhang, B.-H.; Lei, L.-S.; Liu, S.-Z.; Mou, X.-Q.; Liu, W.-T.; Wang, S.-H.; Wang, J.; Bao, W.; Zhang, K., Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles. Chemical Communications 2017,53 (61), 8545-8548;

4.Liu, W.-T.; Xu, Z.-L.; Mou, X.-Q.; Zhang, B.-H.; Bao, W.; Wang, S.-H.; Lee, D.; Lei, L.-S.; Zhang, K., The synthesis of cycloalka[b]furans via an Au(i)-catalyzed tandem reaction of 3-yne-1,2-diols. organic & Biomolecular Chemistry 2017,15 (30), 6333-6337;

5.Zhang, X.-M.; Tu, Y.-Q.; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H., Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis. Chem. Soc. Rev. 2017,46 (8), 2272-2305;

6.Xu, X.-T.; Mou, X.-Q.; Xi, Q.-M.; Liu, W.-T.; Liu, W.-F.; Sheng, Z.-J.; Zheng, X.; Zhang, K.; Du, Z.-Y.; Zhao, S.-Q.; Wang, S.-H., Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice. Bioorg. Med. Chem. Lett. 2016,26 (21), 5334-5339;

7.Wang, J.; Mou, X.-Q.; Zhang, B.-H.; Liu, W.-T.; Yang, C.; Xu, L.; Xu, Z.-L.; Wang, S.-H.*, A metal-free addition/dearomatization cyclization/decarboxylation cascade of aryl 3-arylpropiolate toward the synthesis of 1,1-diaryl-2-alkyl-substituted ethylenes. Tetrahedron Lett. 2016,57 (11), 1239-1242;

8.Mou, X.-Q.; Xu, Z.-L.; Xu, L.; Wang, S.-H.; Zhang, B.-H.; Zhang, D.; Wang, J.; Liu, W.-T.; Bao, W., The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction. org. Lett. 2016,18 (16), 4032-4035;

9.Yang, C.; Xu, Z.-L.; Shao, H.; Mou, X.-Q.; Wang, J.; Wang, S.-H.*, A Tin(IV) Chloride Promoted Tandem C-O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes. org. Lett. 2015,17 (21), 5288-5291;

10..Mou, X.-Q.; Xu, Z.-L.; Wang, S.-H.*; Zhu, D.-Y.; Wang, J.; Bao, W.; Zhou, S.-J.; Yang, C.; Zhang, D., An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole. Chem. Commun. 2015,51 (60), 12064-12067;

11..Mou, X.-Q.; Xu, L.; Wang, S.-H.*; Yang, C., Copper-catalyzed dicyanation of N,N-disubstituted formamide. Tetrahedron Lett. 2015,56 (21), 2820-2822;Wang, S.-H.; Li, B.-S.; Tu, Y.-Q., Catalytic asymmetric semipinacol rearrangements. Chem.Commun. 2014,50 (19), 2393-2408;

12..Xu, L.; Mou, X.-Q.; Chen, Z.-M.; Wang, S.-H.*, Copper-catalyzed intermolecular azidocyanation of aryl alkenes. Chem. Commun. 2014,50 (73), 10676-10679;

13..Dou, Q.-Y.; Tu, Y.-Q.*; Zhang, Y.; Tian, J.-M.; Zhang, F.-M.; Wang, S.-H.*, Spiro-Pyrrolidine-Catalyzed Asymmetric Conjugate Addition of Hydroxylamine to Enals and 2,4-Dienals. Adv. Syn. Catal. 2016, 358, 874-879;

14..Zhu, D.-Y.; Zhang, Z.; Mou, X.-Q.; Tu, Y.-Q.*; Zhang, F.-M.; Peng, J.-B.; Wang, S.-H.*; Zhang, S.-Y., Gold(I)/Copper(II)-Cocatalyzed Tandem Cyclization/Semipinacol Reaction: Construction of 6-Aza/Oxa-Spiro[4.5]decane Skeletons and Formal Synthesis of (±)-Halichlorine. Adv. Synth. Catal. 2015,357 (4), 747-752;

15..Zhu, D.-Y.; Xu, M.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Wang, S.-H.*, Catalytic Asymmetric Construction of α-Quaternary Cyclopentanones and Its Application to the Syntheses of (−)-1,14-Herbertenediol and (−)-Aphanorphine. Chem. Eur. J. 2015,21 (44), 15502-15505;

16..Chen, Z.-M.; Zhang, Z.; Tu, Y.-Q.*; Xu, M.-H.; Zhang, F.-M.; Li, C.-C.; Wang, S.-H.*, A Mn(iii)/TEMPO-co-mediated tandem azidation-1,2-carbon migration reaction of allylic silyl ethers. Chem. Commun. 2014,50 (74), 10805-10808;

17..Tian, J.-M.; Zhao, X.; Tu, Y.-Q.*; Gong, W.; Zhang, F.-M.; Zhang, S.-Y.; Wang, S.-H.*, A Synthetic Approach for Constructing the 3/6/6/5-Fused Tetracyclic Skeleton of Tenuipesine A. Chem. Asian J.2014,9 (3), 724-727;

18..Hou, S.-H.; Tu, Y.-Q.*; Liu, L.; Zhang, F.-M.; Wang, S.-H.*; Zhang, X.-M., Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)-Lycojaponicumin C, (−)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Angew. Chem. Int. Ed. 2013,52 (43), 11373-11376;

19..Zhang, Y.-Q.; Zhu, D.-Y.; Li, B.-S.; Tu, Y.-Q.*; Liu, J.-X.; Lu, Y.; Wang, S.-H.*, Palladium-Catalyzed Cascade Process To Construct 1,2,5-Trisubstituted Pyrroles. J. org. Chem. 2012,77 (8), 4167-4170;

20..Zhang, X.-M.; Shao, H.; Tu, Y.-Q.*; Zhang, F.-M.; Wang, S.-H.*, Total Syntheses of (+)-Alopecuridine, (+)-Sieboldine A, and (−)-Lycojapodine A. J. org. Chem. 2012,77 (18), 8174-8181;

21..Wang, S. H.; Tu, Y. Q.; Tang, M., Lewis acid/base induced reactions. Applications of Domino Transformations in organic Synthesis 1, Snyder, S. A., Ed. Thieme: Stuttgart/New York, 2016; pp 269-354;

22..Wang, S. H.; Tu, Y. Q.; Tang, M., 3.16 The Semipinacol Rearrangements. In Comprehensive organic Synthesis II (Second Edition), Knochel, P., Ed. Elsevier: Amsterdam, 2014; pp 795-852;