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师资队伍
缑三虎
职务/职称:副教授 硕导
研 究 所:药剂学研究所
联系电话:
电子邮件:gousanhu@lzu.edu.cn
办 公 室:勤博楼311室
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】

    2022.6-至  今  兰州大学  药学院  副教授

    2019.9-2022.5  兰州大学  生物学流动站  博士后

    2016.9-2019.6  兰州大学  中西医结合临床  博士

    2013.9-2016.6  兰州大学  药剂学  硕士

    2009.9-2013.6  西北师范大学  制药工程  学士

    兰州大学药学院副教授,硕士研究生导师。甘肃省新药临床前研究重点实验室成员,中国医学科学院“多肽药物研究创新单元”成员。《兰州大学学报(医学版)》青年编委。主要从事全新结构的活性多肽药物创制和多肽构建的新药物递送系统研究和天然药物中活性成分产品及其新剂型与新制剂的开发。主持中国博士后基金第14批特别资助(站中)项目,国家自然科学基金青年项目和甘肃省科技计划基金青年项目各1项。参与研究国家自然科学基金项目3项。近年来在Journal of Medicinal Chemistry, British Journal of Pharmacology等药学顶级期刊发表论文30多篇。

    【研究方向】

    全新结构的活性多肽药物创制和多肽构建的新药物递送系统研究

    天然药物中活性成分产品及其新剂型与新制剂的开发

    【主讲课程】

    本科生课程:《药剂学》《生物药剂学与药代动力学》《制药设备与工艺》

    研究生课程:《新型药物递送系统经典案例》


  • 发表论文

    1.Gou S.; Liu J.; He M.; Ni J*., Quantification and bio-assay of α-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch[. Natural Product Research 2016, 30(18):2130-2134.

    2.Gou S.; Huang H.; Chen XY.; …& Ni J.,* Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats[J]. Journal of the Chinese Medical Association 2016, 79(3):111-121.

    3.Gou, S.; Liu, B.; Han, X.; Wang, L.; Zhong, C.; Liang, S.; Liu, H.; Qiang, Y.; Zhang, Y.; Ni, J*., Anti-atherosclerotic effect of Fermentum Rubrum and Gynostemma pentaphyllum mixture in high-fat emulsion- and vitamin D3-induced atherosclerotic rats. Journal of the Chinese Medical Association 2018, 81 (5), 398-408.

    4.Gou, S.; He, M.; Li, BB.; Zhu, N.; & Ni, J*. Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice. Natural Product Research 2020. DOI:10.1080/14786419.2020.18242233

    5.Gou, S.; Wang, L.; Zhong, C.; Chen, X.; Ouyang, X.; Li, B.; Bao, G.; Liu, H.; Zhang, Y.; Ni, J*., A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE-/-mice. British Journal of Pharmacology 2020, 177 (20), 4627-4644. 

    6.Gou, S.; Li, B.; Ouyang, X.; Ba, Z.; Zhong, C.; Ni, J*., Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. Acs Omega 2021, 6 (33), 21359-21367.

    7.Gou, S.; Li, B.; Ouyang, X.; Ba, Z.; Zhong, C.; Zhang, T.; Chang, L.; Zhu, Y.; Zhang, J.; Zhu, N.; Zhang, Y.; Liu, H.; Ni, J*., Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. Journal of Medicinal Chemistry 2021, 64 (15), 11247-11266.

    8.Li, B.; Ouyang, X.; Ba, Z.; Yang, Y.; Zhang, J.; Liu, H.; Zhang, T.; Zhang, F.; Zhang, Y.; Gou, S*.; Ni, J*., Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. Journal of Medicinal Chemistry 2022, 65 (7), 5625-5641.

    9. Ouyang, X.; Li, B.; Yang, Y.; Ba, Z.; Zhang, J.; Zhang, T.; Chang, L.; Zhang, F.; Zhang, Y.; Liu, H.; Gou, S*.; Ni, J*., Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. Journal of Medicinal Chemistry 2022, 65 (20), 13833-13851.

    10.Li, B.; Ouyang, X.; Liu, Y.; Ba, Z.; Yang, Y.; Zhang, J.; Yang, P.; Yang, T.; Wang, Y.; Zhao, Y.; Mao, W.; Zhong, C.; Liu, H.; Zhang, Y.; Gou, S*.; Ni, J*., Novel β-Hairpin Antimicrobial Peptide Containing the β-Turn Sequence of -NG- and the Tryptophan Zippers Facilitate Self-Assembly into Nanofibers, Exhibiting Excellent Antimicrobial Performance. Journal of Medicinal Chemistry 2024. https://doi.org/10.1021/acs.jmedchem.3c02339

    11.Zhang, F.; Yang, P.; Mao, W.; Zhong, C.; Zhang, J.; Chang, L.; Wu, X.; Liu, H.; Zhang, Y.; Gou, S.; Ni, J*., Short, mirror-symmetric antimicrobial peptides centered on -RRR- have broad-spectrum antibacterial activity with low drug resistance and toxicity. Acta Biomaterialia 2022, 154, 145-167.

    12.Chang, L.; Wu, X.; Ran, K.; Tian, Y.; Ouyang, X.; Liu, H.; Gou, S.; Zhang, Y.; Ni, J*., One New Acid-Activated Hybrid Anticancer Peptide by Coupling with a Desirable pH-Sensitive Anionic Partner Peptide. Acs Omega 2023.

    13.Chen, X.; Liu, D.; Gou, S.; Ji, J.; Xue, Z.; Feng, S*., A novel and sensitive colorimetric detection of PABA by asymmetrically functionalized TA-AuNPs-PEG-FITC based on oriented aggregation. Advanced Powder Technology 2021, 32 (10), 3540-3549.

    14.Zhong, C.; Zhang, F.; Yao, J.; Zhu, Y.; Zhu, N.; Zhang, Y.; Liu, H.; Gou, S.; Ni, J*., Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance. Biochemical Pharmacology 2021, 186.

    15.Zhong, C.; Liu, T.; Gou, S.; He, Y.; Zhu, N.; Zhu, Y.; Wang, L.; Liu, H.; Zhang, Y.; Yao, J.; Ni, J*., Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. European Journal of Medicinal Chemistry 2019, 182.

    16.Zhong, C.; Zhang, F.; Zhu, N.; Zhu, Y.; Yao, J.; Gou, S.; Xie, J.; Ni, J*., Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. European Journal of Medicinal Chemistry 2021, 212.

    17.Zhong, C.; Zou, J.; Mao, W.; Yang, P.; Zhang, J.; Gou, S.; Zhang, Y.; Liu, H.; Ni, J*., Structure modification of anoplin for fighting resistant bacteria. European journal of medicinal chemistry 2024, 268, 116276-116276.

    18.Liu, T.; Zhu, N.; Zhong, C.; Zhu, Y.; Gou, S.; Chang, L.; Bao, H.; Liu, H.; Zhang, Y.; Ni, J*., Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin. European Journal of Pharmaceutical Sciences 2020, 152.

    19.Zhong, C.; Zhu, N.; Zhu, Y.; Liu, T.; Gou, S.; Xie, J.; Yao, J.; Ni, J., Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria. European Journal of Pharmaceutical Sciences 2020, 141.

    20.Zhu, N.; Zhong, C.; Liu, T.; Zhu, Y.; Gou, S.; Bao, H.; Yao, J.; Ni, J*., Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. European Journal of Pharmaceutical Sciences 2021, 158.

    21.Zhong, C.; Zhu, Y.; Zhu, N.; Liu, T.; Gou, S.; Zhang, F.; Yao, J.; Xie, J.; Ni, J*., Synthesis and anti-pseudomonal activity of new β-Ala modified analogues of the antimicrobial peptide anoplin. International Journal of Medical Microbiology 2020, 310 (5).

    22.Zhang, T.; Ouyang, X.; Gou, S.; Zhang, Y.; Yan, N.; Chang, L.; Li, B.; Zhang, F.; Liu, H.; Ni, J*., Novel synovial targeting peptide-sinomenine conjugates as a potential strategy for the treatment of rheumatoid arthritis. International Journal of Pharmaceutics 2022, 617.

    23.Chang, L.; Bao, H.; Yao, J.; Liu, H.; Gou, S.; Zhong, C.; Zhang, Y.; Ni, J*., New designed pH-responsive histidine-rich peptides with antitumor activity. Journal of Drug Targeting 2021, 29 (6), 651-659.

    24.Zhang, Y.; Chang, L.; Bao, H.; Wu, X.; Liu, H.; Gou, S.; Zhang, J.; Ni, J*., Constructing new acid-activated anticancer peptide by attaching a desirable anionic binding partner peptide. Journal of Drug Targeting 2022, 30 (9), 973-982.

    25.Zhang, J.; Ouyang, X.; Zhang, F.; Li, B.; Chang, L.; Yang, P.; Mao, W.; Gou, S.; Zhang, Y.; Liu, H.; Yao, J.; Ni, J*., Structure-Activity Relationship Study of Antimicrobial Peptide PE2 Delivered Novel Linear Derivatives with Potential of Eradicating Biofilms and Low Incidence of Drug Resistance. Journal of Medicinal Chemistry 2023, 66 (13), 8526-8544.

    26.Liu, B.; Zhang, W.; Gou, S.; Huang, H.; Yao, J.; Yang, Z.; Liu, H.; Zhong, C.; Liu, B.; Ni, J*.; Wang, R., Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity. Journal of Peptide Science 2017, 23 (11), 824-832.

    27.Chen, X.; Gou, S.; Shi, Z.; Xue, Z.; Feng, S., Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat. Journal of Pharmaceutical Analysis 2019, 9 (4), 266-273.

    28.Zhong, C.; Gou, S.; Liu, T.; Zhu, Y.; Zhu, N.; Liu, H.; Zhang, Y.; Xie, J.; Guo, X.; Ni, J*., Study on the effects of different dimerization positions on biological activity of partial D-Amino acid substitution analogues of Anoplin. Microbial Pathogenesis 2020, 139.

    29.Chen, X.; Ji, J.; Wang, D.; Gou, S.; Xue, Z.; Zhao, L.; Feng, S*., Highly sensitive and selective colorimetric sensing of histidine by NAC functionalized AuNPs in aqueous medium with real sample application. Microchemical Journal 2021, 160.

    30.Liu, D.; Ji, J.; Guo, X.; Gou, S.; Chen, X*., Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines 2023, 14 (2).

    31.Zhang, F.; Zhong, C.; Yao, J.; Zhang, J.; Zhang, T.; Li, B.; Gou, S.; Ni, J*., Antimicrobial peptides-antibiotics combination: An effective strategy targeting drug-resistant Gram-negative bacteria. Peptide Science 2022, 114 (4).

    32.Liu, B.; Huang, H.; Yang, Z.; Liu, B.; Gou, S.; Zhong, C.; Han, X.; Zhang, Y.; Ni, J*.; Wang, R., Design of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy. Peptides 2017, 88, 115-125.


  • 1.2021年6月中国博士后科学基金第14批特别资助(站中)“用于减少抗生素用药量和耐药速度的新型非线性超短抗菌肽的设计,合成和构效关系研究”2021T140289(18万),主持人:缑三虎

    2.2022年9月获得兰州大学引进人才“双一流”建设经费-队伍建设经费-科研启动费(70万),主持人:缑三虎

    3.2022国家自然科学基金青年项目,“采用羟基磷酸化策略提高抗菌肽生物活性的构效关系研究”(82204180)30万,2023.1.1-2025.12.30. 主持人:缑三虎

    4.2022甘肃省自然科学基金青年项目,“以A-21为结构基础的口服型抗菌肽的设计与抗耐药细菌性肺炎活性研究”. 22JR5RA544. 4万. 主持人:缑三虎


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